INTRODUCING PLENVU SUCCESS WITH LESS

The bowel prep cleanse with less to drink

Illustration of woman cleaning
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PLENVU Dosing

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All it takes
is Little PEG

A thorough colonoscopy starts with a successful bowel cleanse. That’s where PLENVU comes in.

PLENVU was created with you in mind. PLENVU delivers a successful colon cleanse, with less total fluid to drink than other bowel preps.

Also, twice as many people found the taste "very acceptable" compared to those who took another leading bowel prep.

Illustration of a woman about to drink PLENVU® Illustration of a woman about to drink PLENVU®

DID YOU KNOW?

If you prefer to drink PLENVU cold, it can be refrigerated, but must be taken within 6 hours after it's mixed with water

Watch how to take PLENVU

Same-Day Morning-of-Colonoscopy Dosing* Instruction Video

2-Day Split-Dosing Instruction Video

* The “One-Day Morning Dosing Regimen” (as it is labeled in the Prescribing Information) is referred to as “Same-Day Morning-of-Colonoscopy Dosing.”

Getting Started

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How to take PLENVU

There are 2 different ways to take PLENVU: same-day morning-of-colonoscopy dosing* and 2-day split-dosing. Please contact your healthcare provider's office if you’re not sure which way to take it.

It's important to follow the dosing instructions below or as advised by your healthcare provider.

Stay hydrated before, during, and after prep
PLENVU® can be refrigerated, but must be taken within 6 hours after it’s mixed with water
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OPTION 1:
Same-day morning-of-
colonoscopy dosing
*

Same-day-morning-of-colonoscopy-dosing

Note: actual solution is clear.

Stop drinking liquids at least 2 hours before your colonoscopy or as recommended by your healthcare provider.

Take Dose 1 (approximately 3 AM to 7 AM the day of colonoscopy):
  1. Use the mixing container to mix the contents of the Dose 1 pouch with at least 16 ounces of water by shaking or using a spoon until it’s completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.
  2. Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes.

Wait at least 2 hours from the start of Dose 1, then…

Take Dose 2:

  1. Use the mixing container to mix the contents of Dose 2 (Pouch A and Pouch B) with at least 16 ounces of water by shaking or using a spoon until it’s completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.
  2. Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes.
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OPTION 2:
2-day split-dosing

2-day-split-dosing

Note: actual solution is clear.
Stop drinking liquids at least 2 hours before your colonoscopy or as recommended by your healthcare provider.

Take Dose 1 (approximately 4 PM to 8 PM the day before colonoscopy):
  1. Use the mixing container to mix the contents of the Dose 1 pouch with at least 16 ounces of water by shaking or using a spoon until it’s completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.
  2. Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes.

Wait approximately 12 hours from the start of Dose 1, then…

Take Dose 2:

  1. Use the mixing container to mix the contents of Dose 2 (Pouch A and Pouch B) with at least 16 ounces of water by shaking or using a spoon until it's completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.
  2. Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes.

OPTION 1:
Same-day morning-of-
colonoscopy dosing
*

Same-Day Morning-of-Colonoscopy Dosing

Note: actual solution is clear.
Stop drinking liquids at least 2 hours before your colonoscopy or as recommended by your healthcare provider.

Take Dose 1 (approximately 3 AM to 7 AM the day of colonoscopy):
  1. Use the mixing container to mix the contents of the Dose 1 pouch with at least 16 ounces of water by shaking or using a spoon until it’s completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.
  2. Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes.

Wait at least 2 hours from the start of Dose 1, then…

Take Dose 2:

  1. Use the mixing container to mix the contents of Dose 2 (Pouch A and Pouch B) with at least 16 ounces of water by shaking or using a spoon until it’s completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.
  2. Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes.

OPTION 2:
2-day split-dosing

2-Day Split-Dosing

Note: actual solution is clear.
Stop drinking liquids at least 2 hours before your colonoscopy or as recommended by your healthcare provider.

Take Dose 1 (approximately 4 PM to 8 PM the day before colonoscopy):
  1. Use the mixing container to mix the contents of the Dose 1 pouch with at least 16 ounces of water by shaking or using a spoon until it’s completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.
  2. Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes.

Wait approximately 12 hours from the start of Dose 1, then…

Take Dose 2:

  1. Use the mixing container to mix the contents of Dose 2 (Pouch A and Pouch B) with at least 16 ounces of water by shaking or using a spoon until it's completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.
  2. Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes.

IMPORTANT SAFETY INFORMATION

  • Do not take PLENVU if you have a blockage in your intestine (bowel obstruction), an opening in the wall of your stomach or intestine (bowel perforation), problems with food or fluid emptying from your stomach (gastric retention), a problem with food moving too slowly through your intestines (ileus), a very dilated large intestine, or an allergy to any of the ingredients in PLENVU.

Watch how to take PLENVU

Same-Day
Morning-of-Colonoscopy Dosing* Instruction Video

2-Day Split-Dosing Instruction Video

* The "One-Day Morning Dosing Regimen" (as it is labeled in the Prescribing Information) is referred to as "Same-Day Morning-of-Colonoscopy Dosing."

Your PLENVU Schedule

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Fill out this form to find out
when to take PLENVU.*

* Always follow the instructions given to you by your healthcare provider.

1. Day of colonoscopy

2. Time of colonoscopy

Select the schedule prescribed by your healthcare provider. If you are unsure, please call your healthcare provider’s office.

Same-Day
Morning-of-Colonoscopy

OR

2-Day Split-Dosing

Optional: NPO

hours prior to colonoscopy
The “One-Day Morning Dosing Regimen” (as it is labeled in the Prescribing Information) is referred to as “Same-Day Morning-of-Colonoscopy Dosing.”
Calculate

3. Results

Dose 1: on

Dose 2: on

Stop drinking liquids at: on

Time and day of colonoscopy: on

Send

OR

Print

PLENVU Resources

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Cutting-edge support every step of the way

These free resources will help you achieve a successful bowel prep experience.

Peggie cleaning with mop
Co-pay Assistance

Note: for illustrative purposes only.

PLENVU
Savings Program
download resources
Watch the PLENVU dosing videos
2-Day Split-Dosing Instruction Video
Same-Day Morning-of-Colonoscopy Dosing* Instruction Video
* The “One-Day Morning Dosing Regimen” (as it is labeled in the Prescribing Information) is referred to as “Same-Day Morning-of-Colonoscopy Dosing.”
Phone Icon

Need to know more? Call the toll-free PLENVU hotline at 1-855-MY-PLENVU for 24-hour multilingual assistance Sunday, 4 PM to Friday, 8 PM EST.

* The “One-Day Morning Dosing Regimen” (as it is labeled in the Prescribing Information) is referred to as “Same-Day Morning-of-Colonoscopy Dosing.”

PLENVU Co-pay Assistance Card

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PLENVU Savings Program*

PLENVU® Co-pay Assistance Card

Note: for illustrative purposes only.

Download and activate your PLENVU Co-pay Assistance Card today to save on your prescription.

You can either click the “Save now” button below or call 1-855-202-3208 to activate your card. Then, bring your card with you to the pharmacy.

Save now
* Restrictions apply. Not available to patients enrolled in federal, state, or governmental health care programs, including, but not limited to, Medicare, TRICARE, Veterans Administration, Department of Defense, CHAMPUS, the Puerto Rico Government Health Insurance Plan, or any other federal or state health care program.

PLENVU FAQs

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1. What is PLENVU?

PLENVU is a prescription medicine used by adults to clean the colon before a colonoscopy. PLENVU cleans your colon by causing you to have diarrhea (loose stools). Cleaning your colon helps your healthcare provider see the inside of your colon more clearly during your colonoscopy. It is not known if PLENVU is safe and effective in children.
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2. What can I expect with PLENVU?

As with any bowel prep, you will experience watery diarrhea. That means PLENVU is working. The cleaner your colon is, the better view your healthcare provider will have during your colonoscopy. You may expect your first bowel movement 1 to 2 hours after taking Dose 1 of PLENVU. You may feel some bloating or stomach discomfort. If you have severe stomach discomfort or bloating, stop drinking PLENVU for a short time or wait a longer time between each dose until your symptoms improve. You will have a few more bowel movements as you take PLENVU, so make sure you’re near a bathroom.
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3.
 What are the most common side effects of PLENVU?
The most common side effects include nausea, vomiting, dehydration, and stomach pain or discomfort.
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4. How do I take PLENVU?

There are 2 different ways to take PLENVU: same-day morning-of-colonoscopy* dosing and 2-day split-dosing. Please contact your healthcare provider's office if you’re not sure which way to take it. Each schedule has 2 doses. You’ll need to take both doses to complete your prep.

Take Dose 1 (mango flavor)

  1. Use the mixing container to mix the contents of the Dose 1 pouch with at least 16 ounces of water by shaking or using a spoon until it’s completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.

    Mango Flavor
  2. Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes.

Before Starting Dose 2:
For the same-day morning-of-colonoscopy schedule, WAIT AT LEAST 2 HOURS from the start of Dose 1. For the 2-day schedule, WAIT APPROXIMATELY 12 HOURS from the start of Dose 1.

Take Dose 2 (fruit punch flavor)

  1. Use the mixing container to mix the contents of Dose 2 (Pouch A and Pouch B) with at least 16 ounces of water by shaking or using a spoon until it’s completely dissolved. This may take up to 2 to 3 minutes. Take your time—slowly drink and finish the dose within 30 minutes.

    Fruit Punch Flavor
  2. Refill the container with at least 16 ounces of clear liquid. Again, take your time and slowly finish all of it within 30 minutes.

Do not drink alcohol, milk, red or purple colored liquids, or drinks containing pulp.

With both dosing regimens, you'll need to stop drinking clear liquids at least 2 hours before your colonoscopy or as recommended by your healthcare provider.

* The “One-Day Morning Dosing Regimen” (as it is labeled in the Prescribing Information) is referred to as “Same-Day Morning-of-Colonoscopy Dosing.”
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5. What can I drink with PLENVU?

It’s important to stay hydrated before, during, and after taking PLENVU to help prevent fluid loss (dehydration). You don’t need to drink only water—you can have your choice of clear liquids. Remember: these are liquids you can drink in addition to your PLENVU bowel prep. These are not liquids you can use to mix with PLENVU.

Do not drink alcohol, milk, red or purple colored liquids, or drinks containing pulp.

Examples of clear liquids include:

  • Clear soda (ginger ale, root beer)
  • Sports drinks (nothing colored red or purple)
  • Clear broth soups
  • Strained clear fruit juice (without pulp)
  • Strained lemonade or limeade
  • Coffee/tea (without milk or creamer)
  • Gelatin (without fruit or toppings; nothing colored red or purple)
  • Popsicles (without pieces of fruit or pulp; nothing colored red or purple)

You’ll need to stop drinking clear liquids at least 2 hours before your colonoscopy or as recommended by your healthcare provider.

Phone Icon

Need to know more? Call the toll-free PLENVU hotline at 1-855-MY-PLENVU with any questions or concerns you may have throughout your prep process (multilingual assistance Sunday, 4 PM to Friday, 8 PM EST)

 
 
SEE MORE
INDICATION

PLENVU® (polyethylene glycol 3350, sodium ascorbate, sodium sulfate, ascorbic acid, sodium chloride, and potassium chloride for oral solution) is a prescription medication used by adults to clean the colon before a colonoscopy.

IMPORTANT SAFETY INFORMATION
  • Do not take PLENVU if you have a blockage in your intestine (bowel obstruction), an opening in the wall of your stomach or intestine (bowel perforation), problems with food or fluid emptying from your stomach (gastric retention), a problem with food moving too slowly through your intestines (ileus), a very dilated large intestine, or an allergy to any of the ingredients in PLENVU.
  • It is important to drink sufficient clear liquids before, during, and after the use of PLENVU. Be sure to consume additional clear liquids after the first dose and second dose of PLENVU. Stop drinking liquids 2 hours prior to colonoscopy.
  • Before you take PLENVU, talk to your doctor if you:
    • Have problems with serious loss of body fluid (dehydration) and changes in blood salts (electrolytes).
    • Have heart problems or take medication that affects your heart. Your doctor may consider obtaining an electrocardiogram (ECG) test if you are at an increased risk for heart rhythm abnormalities.
    • Have a history of seizures or take antiseizure medication.
    • Have kidney problems or take medication that affects kidney function. Your doctor may want to perform blood testing before and after your colonoscopy.
    • Have a history of stomach or bowel problems, such as ulcerative colitis, a bowel blockage, or a suspected opening in the wall of your stomach or intestine.
    • Have problems swallowing, heartburn (gastric reflux), or if you inhale food or fluid into your lungs when eating or drinking (aspirate).
    • Have a condition that destroys red blood cells, called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
    • Are withdrawing from drinking alcohol.
    • Have phenylketonuria (PKU). PLENVU contains aspartame equivalent to 491 mg of phenylalanine per treatment.
    • Are pregnant or plan to become pregnant.
    • Are breastfeeding or plan to breastfeed.
  • PLENVU may affect how other medications work. Tell your doctor about all other medications (including prescription and nonprescription medicines, vitamins, and herbal supplements) you take before you take PLENVU. Do not take oral medications within 1 hour before or after starting each dose of PLENVU.
  • Symptoms of serious allergic reactions may include skin rash, itching, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat, and kidney problems.
  • In clinical studies with PLENVU, the most common side effects in patients taking PLENVU were nausea, vomiting, dehydration, and abdominal pain/discomfort.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183
Email: salixmc@dlss.com

Please click here for full Prescribing Information.